What is Clenbuterol
Clenbuterol (often called just “clen”) is not a steroid, is a sympathomimetic and a Central nervous system stimulant, a specific agonist, stimulating the beta-2 adrenergic receptors. In some countries it is used in medicine as bronholiticeski remedies for the treatment of asthma due to prolonged half-life. However, in the US and the UK it is not permitted.
Athletes and bodybuilders use clenbuterol mainly due to its thermogenic and anti-catabolic effects. The effect of the drug is that it slightly increases internal body temperature. This increases calorie consumption. It is considered that the increase in body temperature of 1° C increases the amount of burning calories by 5%. The results of studies on animals suggest that clenbuterol has anabolic properties. These effects of the drug are mild in humans, probably due to the small number of beta-3 receptors that increase the production of and insulin sensitivity.
The drug is dosed in micrograms. The most common form is the pill, though there are other forms – solutions, nasal sprays and injectable drugs. Note: although the drug is dosed in micrograms, many manufacturers specify the amount of active ingredient in milligrams, so the tablet weight 20 g will be specified 0.02 mg.
Clenbuterol Side Effects
The degree of side effects of clenbuterol depends on the dosages, although those taking the drug say that most of the adverse reactions subside with prolonged use. Careful use of clenbuterol combined with other adrenoceptor agonists as side effects are likely to worsen. For this reason, it is not recommended to take clen with ephedrine, or a combination of ephedrine-caffeine-aspirin.
The most common side effects of Clenbuterol are as follows:
- Muscle tremors (especially hand tremor);
- Muscle cramps;
- Intensification of appetite;
- Hypertension (high blood pressure);
- Possible heart hypertrophy as clen acts on smooth muscle fibers and muscular tissue of the heart;
- In animal studies, was noted phenomena of tissue necrosis of the cardiac muscle.
Given these side effects of the drug not recommended to take stimulants like Clenbuterol, those with cardiac disorders or hypertension. Take the drug with caution in those who are already taking these drugs for treatment. In addition, there is not enough reliable information about the cardiac effects of high doses of the drug in humans.
Recommended Clenbuterol Dosage
It is well known that the use of Clenbuterol inhibits the beta-2 receptors. This is due to the stimulant effect of the drug. So take clen for extended periods without breaks is impractical. It is believed that the alternation of the two days of the drug with two days of break allows you to maintain the susceptibility of the receptors. However, clenbuterol has a relatively long half-life, so the drug continues to operate even in the days breaks. More practical would be a two-week course of the drug for a two-week break. Maximum plasma concentrations of the drug are achieved after 2 to 3 hours after oral administration and elimination half-life is 34 hours. (The study of Zimmer, 1976.)
A gradual increase in the dose recommended to prevent possible severe side effects. As a rule, it is recommended to start a course of taking one pill (20 mg) on the first day, increasing to one tablet daily. Under normal tolerability, on the seventh day the dose is 140 mg (7 pills), and that number should be taken during the second week of the course. To exceed this dose not make sense, as this will cause a glut receptors. In the gradual dose reduction is also not necessary.
In the next cycle of the course, in 5 or 6 weeks, so did not need to gradually increase the dose, starting with one pill since You now know how Your body tolerates the drug. For example, if the first cycle was completed on seven pills a day, then the next, you can start with 4 – 5 tablets and gradually increase up to seven. Further, it should again be limited to 7 or 8 tabs daily.
During the two-week break, if necessary, you can take a mixture of ephedrine-caffeine-aspirin (ECA). ECA will not cause such oppression and desensitization of the receptors as Clen. In comparison with the Clen, ephedrine short half life, so the buds have time to recover from stimulation by adrenaline and noradrenaline. The power of action of ephedrine is also less than Maple, because it is not a specific agonist. It is believed that ephedrine speeds up the conversion of endogenous and exogenous thyroxine into triiodothyronine by activating the enzyme monodeiodination regulating this process. This important property of ephedrine, because the Maple slows down the process of conversion of thyroxine to triiodothyronine. It is worth noting that some bodybuilders take drugs triiodothyronine simultaneously with the Clenbuterol/ECA in the courses of “drying” of the muscles (of course, together with certain anabolic/androgenic steroids) to maintain normal level of triiodothyronine in the blood. The duration of courses of Clen/ECA are usually limited to 12 weeks and sometimes less time.
Women usually take smaller doses than men. The maximum number for a reception is 80 – 120 micrograms (4-6 tablets).
In addition to the fat burning effect of clenbuterol, it is often used as an anti-catabolic drug after the course of steroid medications to maintain muscle mass. In this case, the dose is 40 mg per day.
Because of the prolonged half-life of Clenbuterol is not necessary to divide the daily dose into several intakes. Most people take the entire dose in the morning, though some take the drug before bedtime in order not to suffer from side effects in the waking state.
It is believed that splitting the daily dose into several intakes will help to ease the side effects. The most suitable mode of drug can be chosen according to the reactions of his body.
Muscle cramps – the most common side effect of clenbuterol. They probably occur because of depletion of taurine in the liver in combination with the lack of electrolytes sodium and potassium, and lack of hydration. Taurine helps to strengthen cell membranes and prevents overstimulation of the nervous system. Some studies show that receiving taurine as a Supplement relaxes painful muscle spasms. Japanese scientists have found that the longer the experimental rats were exposed to physical loads, the more taurine they lost muscle. (Study The Original, 2002)
Symptoms of muscle cramps can be alleviated by such means:
- Eating fruits, especially bananas;
- Ensuring adequate hydration of the body;
- Additional supplementation with taurine, 3 – 5 grams a day;
- Potassium, 200 – 400 mg daily before bed on an empty stomach.